Run Saber is a side-scrolling platform game similar in gameplay to Strider. Players assume the role of one or both of the Run Saber characters. Choosing either Sheena with her Ice powers or Allen with his Thunder powers, players must defeat mutant monsters. The Run Sabers can move side to side, jump in the air, attack with a sword, climb along walls or roofs, slide across the ground and drop-kick. Additionally, each character has a special move, which damages everything on the screen with either Ice or Lightning, and which can be activated by collecting orb power-ups. Other power-ups include small health, large health, extra life and a larger sword. Players progress through 5 different levels, often encountering powerful boss and miniboss mutant creatures.